| |
 |
|
Primary prevention of osteoporosis requires building as much bone as possible during the adolescent period of rapid growth. Delaying menarche (and the increased estrogen exposure associated with bone mass development) may reduce breast cancer. Prevention of these two chronic diseases may be in opposition, estrogen being “good” for bone but “bad” for breast cancer. Our objective is to identify modifiable factors in diet and physical activity that simultaneously result in high levels of bone mass development and delayed estrogen exposure associated with menarche, and the timing of influence of those factors. This study will be among the first to describe maturation of Asian adolescent girls. The study will contribute to the prevention of cancer and osteoporosis by identifying the timing and relative contribution of dietary, physical activity, body size factors to female adolescent maturation and bone growth. |
|
